Lewy Body Disease

What is Lewy Body Disease?

Lewy body disease is caused by the degeneration and death of nerve cells in the brain. The name comes from the presence of abnormal spherical structures, called Lewy bodies, which develop inside nerve cells. It is thought that these may contribute to the death of the brain cells. They are named after the doctor who first wrote about them. It is sometimes referred to as Diffuse Lewy body disease.

Lewy body dementia shares characteristics with both Alzheimer’s disease and Parkinson’s disease.
Like Alzheimer’s, it causes confusion. Like Parkinson’s, it can result in rigid muscles, slowed movement and tremors.

The earliest symptoms of these two diseases differ, but reflect the same underlying biological changes in the brain. Over time, people with both diagnoses will develop very similar cognitive, physical, sleep, and behavioral symptoms. The most striking symptom of Lewy body dementia may be its visual hallucinations, which can be one of the first signs of the disorder.

Hallucinations may range from abstract shapes or colors to conversations with deceased loved ones.

Lewy body dementia signs and symptoms may include:

  • Visual hallucinations. Seeing colors, shapes, animals or people may be one of the first symptoms of Lewy body dementia.
  • Movement disorders. Parkinson’s-like signs may include slowed movement, rigid muscles, tremors or a shuffling walk. They may also have difficulties judging distances, often resulting in falls.
  • Fluctuation in mental state so that the person may be lucid and clear at one time and confused, disoriented and bewildered at other times. Typically this fluctuation occurs over a period of hours or even minutes and is not due to any underlying acute physical illness.
  • Delusions. These may consist of false ideas about another person or situation.
  • Cognitive problems. Alzheimer’s-like problems may include confusion, memory loss and reduced attention spans. Difficult with concentration and attention.
  • Sleep difficulties. A sleep disorder can cause you to physically act out your dreams while you’re asleep.

What is the cause?

At present there is no known cause of Lewy body disease, and no known risk factors have been identified. There is no evidence that it is an inherited disease.

How is Lewy Body Disease diognosed?

This type of dementia is diagnosed by taking a careful history of the pattern of symptoms, and by excluding other possible causes such as Vascular dementia and Alzheimer’s disease. A brain scan may reveal brain degeneration, but the Lewy bodies can only be identified by examination of brain tissue after death.

Lewy body disease is similar to Alzheimer’s disease in many ways, and in the past it has sometimes been difficult to distinguish the two. It has only recently been accepted as a disease in its own right. It can occur by itself or together with Alzheimer’s disease and/or Vascular dementia. It may be hard to distinguish Lewy body disease from Parkinson’s disease, and some people with Parkinson’s disease develop a dementia which is similar to that seen in Lewy body disease.

Who gets Lewy Body Disease?

Both men and women can develop this disease, although it is more common in men.

How does Lewy Body Disease progress?

Lewy body disease differs from Alzheimer’s disease in that the progression of the disease is usually more rapid. However, like Alzheimer’s disease it is a degenerative condition, eventually leading to complete dependence. Death is usually a result of another illness, such as pneumonia or an infection. The average lifespan after the onset of symptoms is about seven years.

Is there treatment available?

At present there is no cure for Lewy body disease. Symptoms such as depression and disturbing hallucinations can usually be reduced by medication. However, medications to relieve hallucinations may increase muscle tremors and stiffness. Conversely, anti-Parkinson drugs may make hallucinations worse. Emerging evidence suggests that cholinesterase inhibitor drugs may be quite helpful for some people with this condition. People with this form of dementia are very sensitive to the side effects of neuroleptic drugs such as antipsychotic medications. It is essential all medications are supervised by a specialist to avoid these severe side effects.

Sources:                 http://www.fightdementia.org.au/

                                   http://www.alzheimersreadingroom.com/

One thought on “Lewy Body Disease

  1. Pingback: Remember Me: Linda White | ADN

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s